{"id":36239,"date":"2025-01-22T07:00:16","date_gmt":"2025-01-22T07:00:16","guid":{"rendered":"https:\/\/updates-www.mccdn.io\/vitals\/?p=36239"},"modified":"2025-12-23T00:37:40","modified_gmt":"2025-12-23T00:37:40","slug":"clinical-trial-supports-big-leap-forward-for-kids-with-leukemia","status":"publish","type":"post","link":"https:\/\/updates-www.mccdn.io\/vitals\/clinical-trial-supports-big-leap-forward-for-kids-with-leukemia\/","title":{"rendered":"Clinical trial supports big leap forward for kids with leukemia","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

If you met 6-year-old Kinsley Cuzzetto, one of the first things you might learn is that she loves music. Her dad, Chuck Cuzzetto, describes Kinsley as \u201ca born performer\u201d who belts out renditions of \u201cHound Dog,\u201d among other Elvis tunes, with panache.<\/p>\n

In 2023, this devoted Elvis fan was folding laundry with her dad when he got the phone call that no parent ever wants to receive. Earlier that day he had taken Kinsley to her pediatrician to investigate some intermittent swelling and bruising on the left side of her body.<\/p>\n

\u201cWhen the doctor called, she told us that she had gotten Kinsley\u2019s lab results back and that she likely had leukemia,\u201d Chuck says. \u201cWe needed to go to the emergency room immediately. We were all pretty terrified.\u201d<\/p>\n

At MultiCare Mary Bridge Children\u2019s Hospital<\/a>, they met with Robert Irwin, MD, a pediatric hematologist-oncologist<\/a>. Further tests revealed that Kinsley had B-cell acute lymphoblastic leukemia (B-ALL), a form of cancer that affects white blood cells and bone marrow.<\/p>\n

\u201cDr. Irwin was so empathetic, candid and patient with us,\u201d Chuck says. \u201cHe explained what the path ahead looked like and answered all our questions. We were still in shock, but he helped reassure us that we would get through this.\u201d<\/p>\n

On the go with a blina backpack<\/strong><\/h2>\n

Kinsley\u2019s journey through treatment began with a month-long hospital stay at Mary Bridge Children\u2019s, where she received chemotherapy. Part of her treatment also included participating in a phase 3 clinical trial for blinatumomab (blina), a type of therapy that helps the immune system identify and destroy cancer cells.<\/p>\n

\u201cBlina is the standard frontline treatment for relapsed disease \u2014 where the cancer goes into remission and then comes back,\u201d says Dr. Irwin, who is also a principal investigator for the trial. \u201cWhat we don\u2019t know is how to best use blina for patients who have just been diagnosed with B-ALL.\u201d<\/p>\n

Mary Bridge Children\u2019s is a member of the Children\u2019s Oncology Group<\/a>, the world\u2019s largest network of children\u2019s hospitals and research organizations studying childhood cancers. Research advances achieved through this group have enabled pediatric oncologists like Dr. Irwin to identify children who are at high risk for disease relapse, which includes Kinsley.<\/p>\n

\u201cBlina is generally well tolerated \u2014 with few or no side effects,\u201d Dr. Irwin says. \u201cThe trial aims to find out whether we can eliminate the extra relapse risk for these kids by adding blina to standard chemotherapy.\u201d<\/p>\n

Thanks to a portable IV infusion pump \u2014 one of five donated by the Mary Bridge Brigade<\/a> \u2014 Kinsley could participate in the trial without the burden of another lengthy hospital stay.<\/p>\n

\u201cThe donation of these pumps has been a real game-changer for patients and their families,\u201d says Julianne Pugh*, BSN, BMTCN, RN-CRA, a clinical research associate at the MultiCare Institute for Research & Innovation.**\"Young<\/p>\n

The Research Institute partners with MultiCare facilities like Mary Bridge Children\u2019s, as well as community medical practices, to offer leading-edge research opportunities for pediatric and adult patients.<\/p>\n

Pugh was instrumental in securing the donation from the Mary Bridge Brigade and developing a system to help families manage the portable infusion pumps on an outpatient basis.<\/p>\n

\u201cBefore we had the pumps, patients were required to stay in the hospital for the entire length of the 28-day infusion of blina,\u201d she says. \u201cWith two rounds of infusion, that could mean eight weeks in the hospital. That\u2019s a real burden and resulted in a lot of families declining to participate in the study.\u201d<\/p>\n

Now, following only a two- to three-day hospital stay, as well as education about how to use the pump, patients can receive blina at home. Housed discreetly in a little red backpack, the pump delivers a continuous infusion of blina while allowing patients like Kinsley to live life to the fullest.<\/p>\n

\u201cShe\u2019d run around, play on the playground, dance, sing and just get to be a kid thanks to that pump,\u201d Chuck says. \u201cTo not have to go in and out of the hospital during that part of her treatment has been a gift.\u201d<\/p>\n

Another gift? Progress in the fight against B-ALL, the most common type of childhood leukemia. An interim analysis of the trial showed such remarkable results that the study was closed early.<\/p>\n

When added to chemotherapy, blina produced significantly superior outcomes for pediatric patients with B-ALL compared to chemotherapy alone, reducing the chance of relapse by over 50 percent and improving three-year survival rates by approximately 10 percent.<\/p>\n

A concert to remember<\/strong><\/h2>\n

Today, Kinsley is still in active treatment. In addition to receiving multiple rounds of chemotherapy, she has received two rounds of investigational blina.<\/p>\n

Her journey, as is often the case, has been full of highs and lows. Shortly after her diagnosis, she had to stop attending school and has experienced many of the challenging side effects commonly associated with chemotherapy, such as fatigue and hair loss.<\/p>\n

But through it all, according to Chuck, Kinsley\u2019s spirit has been indomitable and their family has been grateful for the care they\u2019ve received at Mary Bridge Children\u2019s.<\/p>\n

\u201cThe team at Mary Bridge has just been fantastic \u2014 caring and compassionate every step of the way,\u201d Chuck says. \u201cWe developed such great relationships with the nurses and doctors in both the clinic and the hospital. They would go out of their way to make Kinsley smile.\u201d<\/p>\n

In November 2024, Kinsley was well enough to attend the concert of one of her favorite artists, Zach Bryan.<\/p>\n

\u201cKinsley knows most of his songs by heart and Zach\u2019s music has really helped us get through some hard times,\u201d Chuck says. \u201cHer care team helped coordinate her treatment to ensure we could go and experience the concert to the fullest.\u201d<\/p>\n

*This employee no longer works for MultiCare Health System.
\n**The MultiCare Institute for Research & Innovation closed in November 2025. However, MultiCare continues to conduct research at Pulse Heart Institute<\/a>, MultiCare Cancer Institute<\/a> and MultiCare Mary Bridge Children\u2019s<\/a>, among other areas within our organization. To learn more about clinical trial opportunities, talk to your provider or visit ClinicalTrials.gov<\/a>.<\/em><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

If you met 6-year-old Kinsley Cuzzetto, one of the first things you might learn is that she loves music. Her dad, Chuck Cuzzetto, describes Kinsley as \u201ca born performer\u201d who belts out renditions of \u201cHound Dog,\u201d among other Elvis tunes, with panache. In 2023, this devoted Elvis fan was folding laundry with her dad when […]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":367,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[43,67,79,103],"tags":[],"class_list":["post-36239","post","type-post","status-publish","format-standard","hentry","category-cancer","category-kids-health","category-profiles-stories","category-research"],"acf":[],"yoast_head":"\nClinical trial supports big leap forward for kids with leukemia - MultiCare Vitals<\/title>\n<meta name=\"description\" content=\"Cancer drug blinatumomab (blina) improves survival rates for kids who have B-ALL. 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